Genetics of Malignant Hyperthermia
نویسندگان
چکیده
منابع مشابه
The genetics of malignant hyperthermia.
Malignant hyperthermia susceptibility remains the commonest cause of death owing to general anaesthesia. This is despite the availability of presymptomatic testing, admittedly by a highly invasive method, and a recognised treatment for implementation immediately a patient shows signs of developing a crisis. Recently the finding of linkage to markers from chromosome 19q13.1-13.2 and the identifi...
متن کاملGenetics and pathogenesis of malignant hyperthermia.
Malignant hyperthermia (MH) is a potentially life-threatening event in response to anesthetic triggering agents, with symptoms of sustained uncontrolled skeletal muscle calcium homeostasis resulting in organ and systemic failure. Susceptibility to MH, an autosomal dominant trait, may be associated with congenital myopathies, but in the majority of the cases, no clinical signs of disease are vis...
متن کاملMalignant Hyperthermia
''Malignant Hypothermia'' syndrome is a rare, but dangerous occurrence, the aetiology of which is not known. Up to this date 180 cases have been reported. This syndrome i's seen generally in :male children over age of two years, and especially in adolescent males. Also those people with muscular abnormalities are more susciptable to this illnes'S. Anaesthetic agent such as halothane or muscular...
متن کاملMalignant hyperthermia following rhinoplasty: a case report
Malignant hyperthermia is a rare and fatal disorder. A 16-year-old male patient was a candidate for rhinoplasty surgery with no history of disease and previous surgery, negative family history and no history of medication use in the operating room. Maintenance of anesthesia was performed with O2, NO2 (50% -50%) and MAC isoflurane 1. Gradually, from the 80th minute after the start of the operati...
متن کاملRecrudescence of malignant hyperthermia.
RECRUDESCENCE of a malignant hyperthermia (MH) reaction has previously been reported anecdotally, but in this month’s issue of ANESTHESIOLOGY, Burkman et al. present the first detailed evaluation of its incidence and associated factors. Appreciation of the potential for recrudescence of MH reactions is important for the anesthesiologist managing a suspected case because it informs decisions reg...
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ژورنال
عنوان ژورنال: The Scientific World JOURNAL
سال: 2006
ISSN: 1537-744X
DOI: 10.1100/tsw.2006.289